Effects of the Antifungals Voriconazole and Fluconazole on the Pharmacokinetics of S-(+)- and R-(−)-Ibuprofen

Our objective was to study the effects of the antifungals voriconazole and fluconazole on the pharmacokinetics of S-(+)- and R-(−)-ibuprofen. Twelve healthy male volunteers took a single oral dose of 400 mg racemic ibuprofen in a randomized order either alone, after ingestion of voriconazole at 400...

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Bibliografski detalji
Glavni autori: Hynninen, Ville-Veikko, Olkkola, Klaus T., Leino, Kari, Lundgren, Stefan, Neuvonen, Pertti J., Rane, Anders, Valtonen, Mika, Vyyryläinen, Hanna, Laine, Kari
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Clinical Therapeutics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479148/
https://ncbi.nlm.nih.gov/pubmed/16723553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01483-05
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