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A Computational Framework for the Topological Analysis and Targeted Disruption of Signal Transduction Networks
In this article, optimization-based frameworks are introduced for elucidating the input-output structure of signaling networks and for pinpointing targeted disruptions leading to the silencing of undesirable outputs in therapeutic interventions. The frameworks are demonstrated on a large-scale recon...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Biophysical Society
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1479062/ https://ncbi.nlm.nih.gov/pubmed/16617070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.069724 |
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