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A Computational Framework for the Topological Analysis and Targeted Disruption of Signal Transduction Networks
In this article, optimization-based frameworks are introduced for elucidating the input-output structure of signaling networks and for pinpointing targeted disruptions leading to the silencing of undesirable outputs in therapeutic interventions. The frameworks are demonstrated on a large-scale recon...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1479062/ https://ncbi.nlm.nih.gov/pubmed/16617070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.069724 |
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