DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines.

To investigate the physiological function of poly(ADP-ribose) polymerase (PARP), we used a gene targeting strategy to generate mice lacking a functional PARP gene. These PARP -/- mice were exquisitely sensitive to the monofunctional-alkylating agent N -methyl- N -nitrosourea (MNU) and gamma-irradiat...

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Publicado en:	Nucleic Acids Res
Autores principales:	Trucco, C, Oliver, F J, de Murcia, G, Ménissier-de Murcia, J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1998
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147627/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9592149/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.11.2644
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