In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer

Fenofibrate, an agonist of PPAR-alpha, in doses above 25 μM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are potentiated by retinoic acid, an agonist of the retinoid-X-receptor. DNA content analysis shows that G(1)/S phase progression...

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Bibliografiske detaljer
Main Authors: Saidi, Samir A, Holland, Cathrine M, Charnock-Jones, D Stephen, Smith, Stephen K
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2006
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1475879/
https://ncbi.nlm.nih.gov/pubmed/16569247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-5-13
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