Meiotic double-strand breaks in yeast artificial chromosomes containing human DNA.

Meiotic recombination in the yeast Saccharomyces cerevisiae is initiated by double-strand breaks (DSB) in chromosomal DNA. These DSB, which can be mapped in the rad 50S mutant yeast strain, are caused by a topoisomerase II-like enzyme, the protein Spo11. Evidence suggests that this protein is locate...

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Bibliographic Details
Main Authors: Ira, G, Svetlova, E, Filipski, J
Format: Artigo
Language:Inglês
Published: 1998
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC147548/
https://ncbi.nlm.nih.gov/pubmed/9580694
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