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Engrailed-1 Negatively Regulates β-Catenin Transcriptional Activity by Destabilizing β-Catenin via a Glycogen Synthase Kinase-3β–independent Pathway

The Wnt signaling pathway plays a major role in development, and upon deregulation it is implicated in neoplasia. The hallmark of the canonical Wnt signal is the protection of β-catenin from ubiquitination and proteasomal degradation induced by glycogen synthase kinase (GSK)-3β inhibition. The stabi...

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Detalhes bibliográficos
Main Authors: Bachar-Dahan, Liora, Goltzmann, Janna, Yaniv, Abraham, Gazit, Arnona
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474795/
https://ncbi.nlm.nih.gov/pubmed/16571670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-01-0052
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