High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances.

Recent investigations on mechanism of carcinogenesis have demonstrated important quantitative relationships between the induction of neoplasia, the molecular dose of promutagenic DNA adducts and their efficiency for causing base-pair mismatch, and the extent of cell proliferation in target organ. Th...

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Dettagli Bibliografici
Autori principali: Swenberg, J A, Richardson, F C, Boucheron, J A, Deal, F H, Belinsky, S A, Charbonneau, M, Short, B G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1987
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474488/
https://ncbi.nlm.nih.gov/pubmed/3447904
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