High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances.

Recent investigations on mechanism of carcinogenesis have demonstrated important quantitative relationships between the induction of neoplasia, the molecular dose of promutagenic DNA adducts and their efficiency for causing base-pair mismatch, and the extent of cell proliferation in target organ. Th...

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Detalhes bibliográficos
Main Authors: Swenberg, J A, Richardson, F C, Boucheron, J A, Deal, F H, Belinsky, S A, Charbonneau, M, Short, B G
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474488/
https://ncbi.nlm.nih.gov/pubmed/3447904
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