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The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels

The most serious side-effect of the widely used aminoglycoside antibiotics is irreversible intracellular damage to the auditory and vestibular hair cells of the inner ear. The mechanism of entry into the hair cells has not been unequivocally resolved. Here we report that extracellular dihydrostrepto...

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Autori principali: Marcotti, Walter, van Netten, Sietse M, Kros, Corné J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474200/
https://ncbi.nlm.nih.gov/pubmed/15994187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.085951
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