Migration of human melanoma cells depends on extracellular pH and Na(+)/H(+) exchange

Their glycolytic metabolism imposes an increased acid load upon tumour cells. The surplus protons are extruded by the Na(+)/H(+) exchanger (NHE) which causes an extracellular acidification. It is not yet known by what mechanism extracellular pH (pH(e)) and NHE activity affect tumour cell migration a...

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Bibliografiska uppgifter
Huvudupphovsmän: Stock, Christian, Gassner, Birgit, Hauck, Christof R, Arnold, Hannelore, Mally, Sabine, Eble, Johannes A, Dieterich, Peter, Schwab, Albrecht
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 2005
Ämnen:
Cell Physiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474168/
https://ncbi.nlm.nih.gov/pubmed/15946960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.088344
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