Promoter Mutations That Increase Amyloid Precursor-Protein Expression Are Associated with Alzheimer Disease

Genetic variations in promoter sequences that alter gene expression play a prominent role in increasing susceptibility to complex diseases. Also, expression levels of APP are essentially regulated by its core promoter and 5′ upstream regulatory region and correlate with amyloid β levels in Alzheimer...

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Main Authors: Theuns, Jessie, Brouwers, Nathalie, Engelborghs, Sebastiaan, Sleegers, Kristel, Bogaerts, Veerle, Corsmit, Ellen, De Pooter, Tim, van Duijn, Cornelia M., De Deyn, Peter P., Van Broeckhoven, Christine
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Human Genetics 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474091/
https://ncbi.nlm.nih.gov/pubmed/16685645
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