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New, extended hairpin form of the TAR-2 RNA domain points to the structural polymorphism at the 5′ end of the HIV-2 leader RNA

The HIV-2 TAR RNA domain (TAR-2) plays a key role in the trans-activation of HIV-2 transcription as it is the target for the Tat-2 protein and several cell factors. Here, we show that the TAR-2 domain exists in vitro in two global, alternative forms: a new, extended hairpin form with two conformers...

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Autori principali: Pachulska-Wieczorek, Katarzyna, Purzycka, Katarzyna J., Adamiak, Ryszard W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474061/
https://ncbi.nlm.nih.gov/pubmed/16738137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl373
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