Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex

The nucleolar PeBoW-complex, consisting of Pes1, Bop1 and WDR12, is essential for cell proliferation and processing of ribosomal RNA in mammalian cells. Here we have analysed the physical and functional interactions of Pes1 deletion mutants with the PeBoW-complex. Pes1 mutants M1 and M5, with N- and...

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Autores principales: Grimm, Thomas, Hölzel, Michael, Rohrmoser, Michaela, Harasim, Thomas, Malamoussi, Anastassia, Gruber-Eber, Anita, Kremmer, Elisabeth, Eick, Dirk
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474060/
https://ncbi.nlm.nih.gov/pubmed/16738141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl378
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