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Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

The E6 oncoprotein of human papillomaviruses (HPVs) that are associated with cervical cancer utilizes the cellular ubiquitin–protein ligase E6-AP to target the tumor suppressor p53 for degradation. In normal cells (i.e., in the absence of E6), p53 is also a target of the ubiquitin–proteasome pathway...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hengstermann, Arnd, Linares, Laetitia K., Ciechanover, Aaron, Whitaker, Noel J., Scheffner, Martin
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The National Academy of Sciences 2001
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC14735/
https://ncbi.nlm.nih.gov/pubmed/11158620
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