Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
The E6 oncoprotein of human papillomaviruses (HPVs) that are associated with cervical cancer utilizes the cellular ubiquitin–protein ligase E6-AP to target the tumor suppressor p53 for degradation. In normal cells (i.e., in the absence of E6), p53 is also a target of the ubiquitin–proteasome pathway...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158620/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.031470698 |
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