Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

The E6 oncoprotein of human papillomaviruses (HPVs) that are associated with cervical cancer utilizes the cellular ubiquitin–protein ligase E6-AP to target the tumor suppressor p53 for degradation. In normal cells (i.e., in the absence of E6), p53 is also a target of the ubiquitin–proteasome pathway...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hengstermann, Arnd, Linares, Laetitia K., Ciechanover, Aaron, Whitaker, Noel J., Scheffner, Martin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158620/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.031470698
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