1-Deazaadenosine: synthesis and activity of base-modified hammerhead ribozymes.
The incorporation of 1-deazaadenosine (c1A, 1b) into a hammerhead ribozyme and the resulting catalytic activity is described. For this purpose the phosphoramidite 2a and the 3'-phosphonate 2b as well as Fractosil-linked 1-deazaadenosine (3b) were prepared. The methoxyacetyl group was used for the 6-...
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| Publicado en: | Nucleic Acids Res |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
1998
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147336/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9461461/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.4.1010 |
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