1-Deazaadenosine: synthesis and activity of base-modified hammerhead ribozymes.

The incorporation of 1-deazaadenosine (c1A, 1b) into a hammerhead ribozyme and the resulting catalytic activity is described. For this purpose the phosphoramidite 2a and the 3'-phosphonate 2b as well as Fractosil-linked 1-deazaadenosine (3b) were prepared. The methoxyacetyl group was used for the 6-...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Seela, F, Debelak, H, Usman, N, Burgin, A, Beigelman, L
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1998
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147336/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9461461/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.4.1010
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