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Why Do Hubs Tend to Be Essential in Protein Networks?
The protein–protein interaction (PPI) network has a small number of highly connected protein nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centra...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2006
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1473040/ https://ncbi.nlm.nih.gov/pubmed/16751849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020088 |
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