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Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality

The centrality-lethality rule, which notes that high-degree nodes in a protein interaction network tend to correspond to proteins that are essential, suggests that the topological prominence of a protein in a protein interaction network may be a good predictor of its biological importance. Even thou...

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Autors principals: Zotenko, Elena, Mestre, Julian, O'Leary, Dianne P., Przytycka, Teresa M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2467474/
https://ncbi.nlm.nih.gov/pubmed/18670624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000140
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