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Why Do Hubs Tend to Be Essential in Protein Networks?

The protein–protein interaction (PPI) network has a small number of highly connected protein nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centra...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: He, Xionglei, Zhang, Jianzhi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1473040/
https://ncbi.nlm.nih.gov/pubmed/16751849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020088
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