Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239

The goal of an AIDS vaccine regimen designed to induce cellular immune responses should be to reduce the viral set point and preserve memory CD4 lymphocytes. Here we investigated whether vaccine-induced cellular immunity in the absence of any Env-specific antibodies can control viral replication fol...

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Main Authors: Wilson, Nancy A., Reed, Jason, Napoe, Gnankang S., Piaskowski, Shari, Szymanski, Andy, Furlott, Jessica, Gonzalez, Edna J., Yant, Levi J., Maness, Nicholas J., May, Gemma E., Soma, Taeko, Reynolds, Matthew R., Rakasz, Eva, Rudersdorf, Richard, McDermott, Adrian B., O'Connor, David H., Friedrich, Thomas C., Allison, David B., Patki, Amit, Picker, Louis J., Burton, Dennis R., Lin, Jing, Huang, Lingyi, Patel, Deepa, Heindecker, Gwendolyn, Fan, Jiang, Citron, Michael, Horton, Melanie, Wang, Fubao, Liang, Xiaoping, Shiver, John W., Casimiro, Danilo R., Watkins, David I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472612/
https://ncbi.nlm.nih.gov/pubmed/16731926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00171-06
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