Blocking of Interferon-Induced Jak-Stat Signaling by Japanese Encephalitis Virus NS5 through a Protein Tyrosine Phosphatase-Mediated Mechanism

Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes severe human disease, has been shown to block the interferon (IFN)-induced Janus kinase signal transducer and activation of transcription (Jak-Stat) signaling cascade by preventing Tyk2 tyrosine phosphorylation and Stat activ...

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Bibliographic Details
Main Authors: Lin, Ren-Jye, Chang, Bi-Lan, Yu, Han-Pang, Liao, Ching-Len, Lin, Yi-Ling
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472572/
https://ncbi.nlm.nih.gov/pubmed/16731929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02714-05
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