3-O-(3′,3′-Dimethysuccinyl) Betulinic Acid Inhibits Maturation of the Human Immunodeficiency Virus Type 1 Gag Precursor Assembled In Vitro

3-O-(3′,3′-Dimethysuccinyl) betulinic acid (PA-457) has been shown to potently inhibit human immunodeficiency virus (HIV) replication in culture. In contrast to inhibitors that act upon the viral proteinase, PA-457 appears to block only the final maturational cleavage of p25CA-p2 to p24CA. However,...

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Bibliographic Details
Main Authors: Sakalian, Michael, McMurtrey, Curtis P., Deeg, Frederick J., Maloy, Christopher W., Li, Feng, Wild, Carl T., Salzwedel, Karl
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472563/
https://ncbi.nlm.nih.gov/pubmed/16731910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02743-05
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