Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility

The human TGFB1 gene is polymorphic, and genetic variants are associated with altered cancer risk. However, human genetic association studies have had variable outcomes because TGFβ1 action is context-dependent. We used the murine skin model of chemical carcinogenesis in genetic linkage analysis of...

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Detalhes bibliográficos
Main Authors: Mao, Jian-Hua, Saunier, Elise F., de Koning, John P., McKinnon, Margaret M., Higgins, Mamie Nakijama, Nicklas, Kathy, Yang, Hai-Tao, Balmain, Allan, Akhurst, Rosemary J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472440/
https://ncbi.nlm.nih.gov/pubmed/16702541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602581103
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