Activation of FIP1L1-PDGFRα requires disruption of the juxtamembrane domain of PDGFRα and is FIP1L1-independent

Genetic abnormalities that result in expression of chimeric tyrosine kinase proteins such as BCR-ABL1 and ETV6-PDGFRβ are common causes of hematopoietic malignancies. The paradigm for constitutive activation of these fusion tyrosine kinases is enforced homodimerization by self-association domains pr...

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Bibliographische Detailangaben
Hauptverfasser: Stover, Elizabeth H., Chen, Jing, Folens, Cedric, Lee, Benjamin H., Mentens, Nicole, Marynen, Peter, Williams, Ifor R., Gilliland, D. Gary, Cools, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472432/
https://ncbi.nlm.nih.gov/pubmed/16690743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601192103
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