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Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain

The two-headed kinesin motor harnesses the energy of ATP hydrolysis to take 8-nm steps, walking processively along a microtubule, alternately stepping with each of its catalytic heads in a hand-over-hand fashion. Two persistent challenges for models of kinesin motility are to explain how the two hea...

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Autors principals: Guydosh, Nicholas R., Block, Steven M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472428/
https://ncbi.nlm.nih.gov/pubmed/16698928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600931103
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