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Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain
The two-headed kinesin motor harnesses the energy of ATP hydrolysis to take 8-nm steps, walking processively along a microtubule, alternately stepping with each of its catalytic heads in a hand-over-hand fashion. Two persistent challenges for models of kinesin motility are to explain how the two hea...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1472428/ https://ncbi.nlm.nih.gov/pubmed/16698928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600931103 |
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