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Examining kinesin processivity within a general gating framework
Kinesin-1 is a dimeric motor that transports cargo along microtubules, taking 8.2-nm steps in a hand-over-hand fashion. The ATP hydrolysis cycles of its two heads are maintained out of phase by a series of gating mechanisms, which lead to processive runs averaging ∼1 μm. A key structural element for...
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| 發表在: | eLife |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4453223/ https://ncbi.nlm.nih.gov/pubmed/25902401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07403 |
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