N-Glycans on Nipah Virus Fusion Protein Protect against Neutralization but Reduce Membrane Fusion and Viral Entry

Nipah virus (NiV) is a deadly emerging paramyxovirus. The NiV attachment (NiV-G) and fusion (NiV-F) envelope glycoproteins mediate both syncytium formation and viral entry. Specific N-glycans on paramyxovirus fusion proteins are generally required for proper conformational integrity and biological f...

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Hlavní autoři: Aguilar, Hector C., Matreyek, Kenneth A., Filone, Claire Marie, Hashimi, Sara T., Levroney, Ernest L., Negrete, Oscar A., Bertolotti-Ciarlet, Andrea, Choi, Daniel Y., McHardy, Ian, Fulcher, Jennifer A., Su, Stephen V., Wolf, Mike C., Kohatsu, Luciana, Baum, Linda G., Lee, Benhur
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472062/
https://ncbi.nlm.nih.gov/pubmed/16641279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.10.4878-4889.2006
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