Endothelial Galectin-1 Binds to Specific Glycans on Nipah Virus Fusion Protein and Inhibits Maturation, Mobility, and Function to Block Syncytia Formation

Nipah virus targets human endothelial cells via NiV-F and NiV-G envelope glycoproteins, resulting in endothelial syncytia formation and vascular compromise. Endothelial cells respond to viral infection by releasing innate immune effectors, including galectins, which are secreted proteins that bind t...

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Detalhes bibliográficos
Main Authors: Garner, Omai B., Aguilar, Hector C., Fulcher, Jennifer A., Levroney, Ernest L., Harrison, Rebecca, Wright, Lacey, Robinson, Lindsey R., Aspericueta, Vanessa, Panico, Maria, Haslam, Stuart M., Morris, Howard R., Dell, Anne, Lee, Benhur, Baum, Linda G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904771/
https://ncbi.nlm.nih.gov/pubmed/20657665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000993
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