Lambda Interferon (IFN-λ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo

Type III interferons (IFNs) (interleukin-28/29 or lambda interferon [IFN-λ]) are cytokines with IFN-like activities. Here we show that several classes of viruses induce expression of IFN-λ1 and -λ2/3 in similar patterns. The IFN-λs were—unlike alpha/beta interferon (IFN-α/β)—induced directly by stim...

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Bibliographic Details
Main Authors: Ank, Nina, West, Hans, Bartholdy, Christina, Eriksson, Kristina, Thomsen, Allan R., Paludan, Søren R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472004/
https://ncbi.nlm.nih.gov/pubmed/16611910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4501-4509.2006
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