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Recognition of GC base pairs by triplex forming oligonucleotides containing nucleosides derived from 2-aminopyridine.

We have attempted to alleviate the pH dependency of triplex recognition of guanine by using intermolecular triplexes containing 2-amino-5-(2-deoxy-d-ribofuranosyl)pyridine (AP) as an analogue of 2'-deoxycytidine (dC). We find that for the beta-anomer of AP, the complex between (AP)6T6and the target...

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Udgivet i:Nucleic Acids Res
Principais autores: Cassidy, S A, Slickers, P, Trent, J O, Capaldi, D C, Roselt, P D, Reese, C B, Neidle, S, Fox, K R
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147136/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9396793/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.24.4891
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