Recognition of GC base pairs by triplex forming oligonucleotides containing nucleosides derived from 2-aminopyridine.

We have attempted to alleviate the pH dependency of triplex recognition of guanine by using intermolecular triplexes containing 2-amino-5-(2-deoxy-d-ribofuranosyl)pyridine (AP) as an analogue of 2'-deoxycytidine (dC). We find that for the beta-anomer of AP, the complex between (AP)6T6and the ta...

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Detalhes bibliográficos
Main Authors: Cassidy, S A, Slickers, P, Trent, J O, Capaldi, D C, Roselt, P D, Reese, C B, Neidle, S, Fox, K R
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC147136/
https://ncbi.nlm.nih.gov/pubmed/9396793
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