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Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design?

A safe and effective HIV-1 vaccine is urgently needed to control the worldwide AIDS epidemic. Traditional methods of vaccine development have been frustratingly slow, and it is becoming increasingly apparent that radical new approaches may be required. Computational and mathematical approaches, comb...

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Detalhes bibliográficos
Main Authors: de Oliveira, Tulio, Salemi, Marco, Gordon, Michelle, Vandamme, Anne-Mieke, van Rensburg, Estrelita Janse, Engelbrecht, Susan, Coovadia, Hoosen M, Cassol, Sharon
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1470929/
https://ncbi.nlm.nih.gov/pubmed/15280222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.103.018135
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