Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design?

A safe and effective HIV-1 vaccine is urgently needed to control the worldwide AIDS epidemic. Traditional methods of vaccine development have been frustratingly slow, and it is becoming increasingly apparent that radical new approaches may be required. Computational and mathematical approaches, comb...

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Hlavní autoři: de Oliveira, Tulio, Salemi, Marco, Gordon, Michelle, Vandamme, Anne-Mieke, van Rensburg, Estrelita Janse, Engelbrecht, Susan, Coovadia, Hoosen M, Cassol, Sharon
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1470929/
https://ncbi.nlm.nih.gov/pubmed/15280222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.103.018135
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