Interaction of endostatin with integrins implicated in angiogenesis

Endostatin, a fragment of collagen XVIII, is a potent antagonist of angiogenesis and inhibitor of tumor growth in mouse models. At present, the mechanism of action of endostatin is unknown. We show here that recombinantly produced human endostatin interacts with α(5)- and α(v)-integrins on the surfa...

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Autores principales: Rehn, Marko, Veikkola, Tanja, Kukk-Valdre, Eola, Nakamura, Hitoshi, Ilmonen, Maritta, Lombardo, Christian R., Pihlajaniemi, Taina, Alitalo, Kari, Vuori, Kristiina
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2001
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC14702/
https://ncbi.nlm.nih.gov/pubmed/11158588
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