Interaction of endostatin with integrins implicated in angiogenesis

Endostatin, a fragment of collagen XVIII, is a potent antagonist of angiogenesis and inhibitor of tumor growth in mouse models. At present, the mechanism of action of endostatin is unknown. We show here that recombinantly produced human endostatin interacts with α(5)- and α(v)-integrins on the surfa...

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Main Authors: Rehn, Marko, Veikkola, Tanja, Kukk-Valdre, Eola, Nakamura, Hitoshi, Ilmonen, Maritta, Lombardo, Christian R., Pihlajaniemi, Taina, Alitalo, Kari, Vuori, Kristiina
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2001
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC14702/
https://ncbi.nlm.nih.gov/pubmed/11158588
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