Interaction of endostatin with integrins implicated in angiogenesis

Endostatin, a fragment of collagen XVIII, is a potent antagonist of angiogenesis and inhibitor of tumor growth in mouse models. At present, the mechanism of action of endostatin is unknown. We show here that recombinantly produced human endostatin interacts with α(5)- and α(v)-integrins on the surfa...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rehn, Marko, Veikkola, Tanja, Kukk-Valdre, Eola, Nakamura, Hitoshi, Ilmonen, Maritta, Lombardo, Christian R., Pihlajaniemi, Taina, Alitalo, Kari, Vuori, Kristiina
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14702/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158588/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.031564998
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