Cytochromes P450 in benzene metabolism and involvement of their metabolites and reactive oxygen species in toxicity.

Cytochrome P450 (CYP) 2E1 was the most efficient CYP enzyme that oxidized benzene to soluble and covalently bound metabolites in rat and human liver microsomes. The covalent binding was due mostly to the formation of benzoquinone (BQ), the oxidation product of hydroquinone (HQ), and was inversely re...

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Dettagli Bibliografici
Autori principali: Gut, I, Nedelcheva, V, Soucek, P, Stopka, P, Tichavská, B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1469770/
https://ncbi.nlm.nih.gov/pubmed/9118895
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