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The use of protein adducts to investigate the disposition of reactive metabolites of benzene.

Benzene is metabolized to a number of electrophilic species that are capable of binding to both DNA and proteins. We used adducts of hemoglobin (Hb) and bone marrow proteins to study the disposition of three benzene and metabolites (benzene oxide [BO], 1,2-benzoquinone [1,2-BQ], and 1,4-benzoquinone...

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Main Authors: Rappaport, S M, McDonald, T A, Yeowell-O'Connell, K
Formato: Artigo
Idioma:Inglês
Publicado: 1996
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1469719/
https://ncbi.nlm.nih.gov/pubmed/9118898
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