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Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program

Loss of growth inhibitory responses to the cytokine transforming growth factor β (TGF-β) in cancer cells may result from mutational inactivation of TGF-β receptors or their signal transducers, the Smad transcription factors. In breast cancer, however, loss of TGF-β growth inhibition often occurs wit...

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Autors principals: Chen, Chang-Rung, Kang, Yibin, Massagué, Joan
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC14697/
https://ncbi.nlm.nih.gov/pubmed/11158583
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