A competitive enzyme hybridization assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides.

An enzyme competitive hybridization assay was developed and validated for determination of mouse plasma concentrations of a 15mer antisense phosphodiester oligodeoxyribonucleotide and of two phosphorothioate analogs. Assays were performed in 96-well microtiter plates. The phosphodiester sense sequen...

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Publicado en:	Nucleic Acids Res
Autores principales:	Deverre, J R, Boutet, V, Boquet, D, Ezan, E, Grassi, J, Grognet, J M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146941/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9278477/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.18.3584
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