Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides
Chemically modified antisense oligonucleotides with phosphorothioate linkages (PS-ASOs) mediate site-specific cleavage of RNA by RNase H1 and are broadly used as research and therapeutic tools. PS-ASOs can enter cells via endocytic pathways and escape from membrane-enclosed endocytic organelles to r...
Salvato in:
| Autori principali: | , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2018-12-01
|
| Serie: | Molecular Therapy: Nucleic Acids |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2162253118302828 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|