Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site.
Interleukin-6 (IL-6) is a multifunctional cytokine thought to be a key factor in post-menopausal osteoporosis, given its ability to induce osteoclast maturation and its down regulation by estrogens. We have previously shown that the effects of TNFalphaand estradiol on the human IL-6 promoter were de...
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| Опубликовано в:: | Nucleic Acids Res |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
1997
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146754/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9171095/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.12.2424 |
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