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Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site.
Interleukin-6 (IL-6) is a multifunctional cytokine thought to be a key factor in post-menopausal osteoporosis, given its ability to induce osteoclast maturation and its down regulation by estrogens. We have previously shown that the effects of TNFalphaand estradiol on the human IL-6 promoter were de...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1997
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC146754/ https://ncbi.nlm.nih.gov/pubmed/9171095 |
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