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Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene.

CTCF belongs to the Zn finger transcription factors family and binds to the promoter region of c-myc. CTCF is highly conserved between species, ubiquitous and localised in nuclei. The endogenous CTCF migrates as a 130 kDa (CTCF-130) protein on SDS-PAGE, however, the open reading frame (ORF) of the C...

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Udgivet i:Nucleic Acids Res
Principais autores: Klenova, E M, Nicolas, R H, U, S, Carne, A F, Lee, R E, Lobanenkov, V V, Goodwin, G H
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146483/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9016583/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.3.466
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