Tracking germinal center B cells expressing germ-line immunoglobulin γ1 transcripts by conditional gene targeting

Germinal centers (GCs) represent the main sites for the generation of high-affinity, class-switched antibodies during T cell-dependent antibody responses. To study gene function specifically in GC B cells, we generated Cγ1-cre mice in which the expression of Cre recombinase is induced by transcripti...

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Bibliographic Details
Main Authors: Casola, Stefano, Cattoretti, Giorgio, Uyttersprot, Nathalie, Koralov, Sergei B., Seagal, Jane, Hao, Zhenyue, Waisman, Ari, Egert, Angela, Ghitza, Dvora, Rajewsky, Klaus
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464351/
https://ncbi.nlm.nih.gov/pubmed/16651521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602353103
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