Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes

Antigen receptor editing—a process of secondary rearrangements of antigen receptor genes in autoreactive lymphocytes—is a well-established tolerance mechanism in B cells, whereas its role in T cells remains controversial. Here, we investigated this issue using a novel Tcra knock-in locus, which ensu...

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Detalhes bibliográficos
Main Authors: Kreslavsky, Taras, Kim, Hye-Jung, Koralov, Sergei B., Ghitza, Dvora, Buch, Thorsten, Cantor, Harvey, Rajewsky, Klaus, von Boehmer, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782038/
https://ncbi.nlm.nih.gov/pubmed/23980099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130876
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