XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice

Inactivation of the XRCC4 nonhomologous end-joining factor in the mouse germ line leads to embryonic lethality, in association with apoptosis of newly generated, postmitotic neurons. We now show that conditional inactivation of the XRCC4 in nestin-expressing neuronal progenitor cells, although leadi...

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Detalhes bibliográficos
Main Authors: Yan, Catherine T., Kaushal, Dhruv, Murphy, Michael, Zhang, Yu, Datta, Abhishek, Chen, Changzhong, Monroe, Brianna, Mostoslavsky, Gustavo, Coakley, Kristen, Gao, Yijie, Mills, Kevin D., Fazeli, Alex P., Tepsuporn, Suprawee, Hall, Giles, Mulligan, Richard, Fox, Edward, Bronson, Roderick, De Girolami, Umberto, Lee, Charles, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464348/
https://ncbi.nlm.nih.gov/pubmed/16670198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601938103
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